Ummm. I may be completely clueless here, but without knowing you or her, I would speculate that maybe dsthe anxiety is rooted in something more than your pending trip. Vacations (and sometimes even pre-vacations and post-vacations) sometimes bring conflicts in couples to the fore that were previusly lurking underground. The vacation triggers it because when you are away from the normal set and setting (work, household responsibilities, family, etc.) its hard to hide behind them. You go thinking that "getting away" will make conflicts and issues go away but it can have the opposite effect. Or, alternatively, you are afraid to go because you are afraid that you and your spouse will have nothing to talk about except what is really bothering you (been there done that....)
Or sometimes, a vacation triggers a power fight. One spouse will plan a trip without consulting the other and the spouse who did not choose that particular trip may be resentful and choose a passive aggressive way of getting out of it instead of coming right out and saying "I don't want to go to Belize, I wanted to go to Atlanta to see my sister but you didn't even ASK me..." etc. Or maybe this was a particularly bad time to plan a vacation due to family or work emergencies?
Alternatively, your wife could even have a touch of agoraphobia; any of those fears are normal, but all of them together are a bit much. Does she normally have anxiety attacks pre-vacation?
All this is to say, you may have a bit of marital work to do or maybe this is a good time for a counseling session or a therapy consult if you and she are so inclined.
If its none of those things, just buy her a copy of one of the travel guides (Lan's latest?) real quick or have her spend some time on this bulletin board (but reassure her you have the SafeSea already packed 'cause she's gonna read the pica pica message thread!)
AmbergrisCaye.com 
